Buffalo Bills at Los Angeles Chargers: Predictions, picks and odds for NFL Week 16 game

The Saturday nightcap will take place in Southern California, with the Los Angeles Chargers (5-9) playing host to the Buffalo Bills (8-6).

Are the Bills back? After a rocky first half of the season, Buffalo is playing like the Super Bowl contender they were expected to be as they collected another win against a playoff contender in the Dallas Cowboys. The Bills put the game out of reach early in the contest and showed flashes of how dangerous this team could be if it continues to be hot late in the season.

The disastrous Chargers season reached a new low last week after giving up 63 points in a whopping loss to the Las Vegas Raiders. Brandon Staley was finally given the boot, as well as general manager Tom Telesco, leaving Los Angeles with not much to play for the rest of the season other than to see what draft pick they get.

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Chargers vs. Bills odds, moneyline, over/under

The Bills are favorites to defeat the Chargers, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023, including the new ESPN BET app.

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• Spread: Bills (-12.5)
• Moneyline: Bills (-800); Chargers (+550)
• Over/under: 44

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NFL Week 16 odds, predictions and picks

Rams vs. Saints | Steelers vs. Bengals | Chargers vs. Bills | Falcons vs. Colts | Panthers vs. Packers | Texans vs. Browns | Vikings vs. Lions | Jets vs. Commanders | Titans vs. Seahawks | Buccaneers vs. Jaguars | Bears vs. Cardinals | Dolphins vs. Cowboys | Broncos vs. Patriots | Chiefs vs. Raiders | Eagles vs. Giants | 49ers vs. Ravens

Lorenzo Reyes: Bills 29, Chargers 14

It will be interesting to see how the Chargers bounce back from Brandon Staley’s firing. Often, teams can get a little bump in the week following a coaching change. But Buffalo is red hot and looks like the most dangerous team in the AFC right now and Los Angeles is still starting Easton Stick. Logic says back the stronger squad, even with the big line.

Tyler Dragon: Bills 31, Chargers 13

The Bills are one of the hottest teams in the NFL right now. Meanwhile, the Chargers, who fired coach Brandon Staley and GM Tom Telesco, are already thinking about next season. One team is pushing for a playoff berth and the other is playing for pride while also thinking about vacation plans. We know how this one will go.

Safid Deen: Bills 27, Chargers 13

The Chargers waived the white flag last Thursday against the Raiders in embarrassing fashion, and the end of the year can’t come fast enough. Meanwhile, the Bills see the road to the postseason within their grasp and should win easily in Los Angeles.

Victoria Hernandez: Bills 27, Chargers 19

Buffalo has a lot of momentum after an upset win. Josh Allen admitted he had a far-from-stellar outing, but it was perfectly fine that James Cook carried the Bills. Los Angeles doesn’t have enough tools to keep up. This is a massive spread for a road game where the Bills have to travel across the country, so take the moneyline.

Jordan Mendoza: Bills 33, Chargers 13

It might be a good thing this game will only be available on Peacock, as it might not be one worth tuning into. The Chargers hit a new low last week, and it won't get any easier going against an offense that has found its rhythm. Buffalo doesn't make this a contest and wins its third straight.

You can view the full list of USA TODAY's NFL expert predictions here.

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